- About A&S
- Research & Teaching Support
Back to Top Nav
- Internal Awards and Fellowships
- External Funding
- Other Dartmouth Support
- Governance & Service
- News & Events
The proper assembly and regulated function of eukaryotic cilia is critical for development and sustained human health. We use a variety of biochemical, molecular, and genetic techniques to elucidate the signal transduction pathways that regulate motor proteins responsible for ciliary beating.
Perrone, C.A., D. Tritschler, R. Bower, E. T. O'Toole, M. J. Wargo, E. F. Smith, and M. E. Porter. BOP2 encodes a novel WD-repeat protein that regulates inner arm dynein activity. (in preparation)
Vasudevan, K.K., K. Song, L.M. Alford, W.S. Sale, E.E. Dymek, E.F Smith, T. Hennessey, E. Joachimiak, P. Urbanska, D. Wloga, W. Dentler, D. Nicastro, and J. Gaertig. (2015) FAP206 is a microtubule-docking adapter for ciliary radial spoke 2 and dynein c. Molecular Biology of the Cell. Feb 15;26(4):696-710.
Wren, K.N., J.M. Craft, D. Tritschler, A. Schauer, D.K. Patel, E.F Smith, M.E. Porter, P. Kner, K.F.Lechtreck. (2013) A differential cargo-loading model of ciliary length regulation by IFT. Current Biology. Dec 16;23(24):2463-71.
DiPetrillo, C. and E.F. Smith. (2013) Methods for analysis of calcium / calmodulin signaling in cilia and flagella. Methods in Enzymology, 524: 37-57.
"Regulation of Ciliary and Flagellar Motility: Understanding the Function of Calmodulin and Interacting Proteins”